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Ageless Forever Anti-Aging News Blog

Niacin Supplements - what you need to know about niacin products

In a previous article I presented the wide array of health benefit of niacin – a.k.a vitamin B3 – supplementation, related to both its lipid and non-lipid effects "Niacin – a.k.a vitamin B3 – the Neglected Broad Spectrum Cholesterol Drug! "
 
In this article you will get critical information about the different niacin products and names, and what to look for when shopping niacin supplements…
 
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Biological Aging in Young Adults - Can it be measured? Does it matter?

Typically, research on aging is done in older people. The problem with studying aging in old people is that most of them already have age-related diseases, which anti-aging interventions aim to prevent. 
 
Age-related changes in the body start to accumulate early in life and affect physiological function years before disease diagnosis; atherosclerosis is a prime example.[1] Thus, intervention to reverse or delay the development of age-related diseases must be done while people are still young [2], before aging-related diseases become established. 
 
Up to this point, the main obstacle to studying aging before old age and before the onset of age-related diseases has been the absence of methods to quantify the pace of aging (i.e. aging rate) in young people. However, a recent study shows that aging processes can be measured in people still young enough for prevention of age-related disease, and that physical manifestations of aging are already present in young adults.[3]
 
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Effects of Testosterone Therapy for 3 Years on Subclinical Atherosclerosis Progression in Older Men

Clinical practice guidelines rely heavily on results from randomized controlled trials (RCTs), which is the gold standard for medical research. RCTs produce evidence considered to be of the highest quality. Because RCTs are resource intensive and costly, they are typically of relatively short duration, commonly lasting for around one year. 
 
Currently there are only a few placebo-controlled RCTs investigating the effects of testosterone therapy for a duration of 3 years [1-4], and medical societies have long been urging for more long-term trials evaluating the safety and efficacy of testosterone therapy.[5-7]
 
On August 11th 2015 a notable 3-year long RCT was published in JAMA (Journal of the American Medical Association), which attracted a lot of attention.[8] While interpreted by many as showing that testosterone therapy does not confer any benefits on atherosclerosis, sexual function and quality of life, a closer look at the data actually shows two important positive results…
 
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Normalization of testosterone level is associated with reduced risk of heart attack, stroke and mortality in men

The effect of testosterone replacement therapy on cardiovascular outcomes such as heart attack and stroke are controversial and have been generating heated discussions among clinicians as well as researchers. This, coupled with biased media sensationalism blowing up the supposed “dangers” of testosterone therapy has created great confusion among suffering men, who could gain tremendous health benefits from testosterone therapy.[1]
 
Here I report the results of a new study that examined the relationship between normalization of total testosterone levels with testosterone therapy and cardiovascular events as well as all-cause mortality, in patients without a previous history of heart attack and stroke.[2] This notable study was published in the European Heart Journal on August 6th, 2015.
 
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Niacin – a.k.a vitamin B3 – the neglected broad spectrum cholesterol drug!

 

Niacin - vitamin B3 - when taken in high dose acts as a powerful cholesterol drug. Niacin is unique among all available cholesterol drugs because it has beneficial effects across the entire lipid/lipoprotein spectrum, including the three components of atherogenic dyslipidemia. 
 
To learn the basics about atherogenic dyslipidemia, see my previous article "Why you need to look beyond your LDL - “bad cholesterol” - level". 
 
Niacin is especially noteworthy because it is the most potent drug available for raising HDL levels.[1, 2] Besides boosting  HDL levels, niacin also markedly lowers triglyceride levels while reducing LDL to a smaller degree.[1]
 
The table below provides an overview of the effects of popular drugs and supplements on blood lipids.[3]
 
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Long-term testosterone treatment with different testosterone preparations - provocative results on diagnosis and adherence

Due to lack of consistent clear-cut guidelines for diagnosis and treatment of testosterone deficiency, there is a lot of confusion among both health professionals and suffering men. The multiple different testosterone preparations available further add to the complexity of testosterone treatment.

This article presents the intriguing results from a notable study that analyzed effects of testosterone therapy with seven different testosterone preparations in symptomatic men who had previously been denied treatment because of “normal” baseline testosterone levels.[1]
 
The results are quite provocative and highlight several important practical issues relating to diagnosis and treatment of hypogonadism…
 
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Risk of Blood Clots in Men Receiving Testosterone Therapy?

Venous thromboembolism is a blood clot that forms in a vein deep inside a part of the body; it mainly affects the large veins in the lower leg and thigh. 
 
Blood clot formation (venous thromboembolism) has been suggested to be one main risk with testosterone replacement therapy. In 2014, both the US Food and Drug Administration (FDA) [1] and Health Canada [2] implemented a requirement for manufacturers to add a warning about the potential risks of venous thromboembolism and deep vein thrombosis to the label of all testosterone products.
 
However, until recently there were no comparative studies examining an association between testosterone replacement therapy and venous thromboembolism. Here we report the results of a recent case-control study - published July 20th 2015 - that specifically examined the risk of venous thromboembolism associated with testosterone therapy in middle-aged and older men.[3]
 
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Artificial Sweeteners and Diet Sodas - do they Help or Hinder Fat Loss?

The potential benefits and risks of artificial sweeteners and diet sodas are hotly debated. Critics state that artificial sweeteners and diet sodas are fueling obesity [1, 2], increasing the risk for diabetes and cardiovascular disease [2, 3], and of causing metabolic derangements.[2]
 
A popular argument against consumption of sweet-tasting but non-caloric or reduced-calorie food and beverages is that this interferes with appetite and physiological energy intake regulation.[2]
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Why you need to look beyond your LDL - “bad cholesterol” - level

In the United States, cardiovascular diseases account for about 1 of every 3 deaths.[1] The cornerstone in heart disease treatment is reducing elevations of LDL, popularly known as the “bad cholesterol” (see table below “What do the terms mean?”) [2, 3], primarily with statins, the most widely used cholesterol/ heart disease drug.[4]  
 
However, when one looks at the aggregate effectiveness of statin treatment in all studies, morbidity and mortality rates among statin-treated patients still remain approximately two thirds to three quarters of those found in patients randomized to placebo.[5, 6] In the “Treating to New Targets” study there were still 80% cases of cardiovascular disease, despite intensive treatment with high-dose statins.[7]
 
Thus, many patients – even those treated aggressively with statins to meet LDL goals - have residual cardiovascular risk.[8-13] This remaining risk is associated with low levels of HDL, increased levels of triglycerides, and elevated numbers of small, dense, atherogenic LDL particles.[8, 10, 11, 14-17] and other common metabolic abnormalities that you will find out about in this article...
 
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Fish Oil for Fat Loss - can it really help you get in shape?

Fish oil is most known for its beneficial heart and cardiovascular effects, and continues to top the list of health promoting supplements. Fish oil is unique in its ability to protect against heart disease and promote cardiovascular health in all people, regardless of age or baseline health status [1, 2].
 
Fish oil improves the blood lipid profile and is especially effective at lowering triglycerides (a.k.a. blood fats).[3] It also has beneficial effects on blood platelet activity, blood thickness, as well as blood vessel (endothelial) function [4-11], blood vessel elasticity [12], and blood pressure [13, 14], among other things.
 
In 2004 FDA approved a prescription fish oil preparation for treatment of high triglycerides (hypertriglyceridemia) [3, 15, 16]. Accumulating research shows that fish oil also has other beneficial effects, which are more visually notable… notably, fat loss!
 
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