Ageless Forever Anti-Aging News Blog

DHEA supplementation in older adults helps reverse arterial aging

  • Published in DHEA

When it comes to health promotion and longevity, DHEA is a supplement which deserves more attention than it has been getting.

DHEA levels (the main circulating form of DHEA in the bloodstream is DHEAS) decrease approximately 80% between ages 25 and 75 year.[1, 2]This large decline in DHEA has led to interest in the possibility that aging related DHEA deficiency may play a role in the deterioration in physiological and metabolic functions with aging, and in the development of chronic diseases.

In support of this, it has been reported that DHEA level is negatively correlated with mortality and risk of developing cardiovascular disease (CVD) (i.e. lower DHEA(S) levels are associated with higher mortality and CVD risk).[3-5]More recently it has been found that a steep decline or extreme variability over time in DHEA(S) levels is associated with higher mortality, more so than baseline DHEA(S) levels.[6]

Aging not only reduces DHEA(S) levels, but also results in an increase in arterial stiffness [7, 8], which is an independent predictor of cardiovascular disease (CVD) risk and mortality.[9-11]

It has been reported that DHEA levels are inversely associated with arterial stiffness (i.e. lower DHEA levels are associated with increased arterial stiffness. [7, 12, 13] Therefore, it is possible that DHEA replacement in older adults could reduce arterial stiffness, and thereby contribute to reduction in CVD and mortality...

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Primary Prevention as an Anti-Aging Strategy - the importance of starting down the right path

Risk factors and chronic diseases typically get most attention among middle-age and older folks. And rightly so, since that's when the manifestations of chronic diseases start to show up, and when people get reminded about their chronological age.
 
An integral component of anti-aging (aka successful aging or healthy aging) is the freedom of physical disabilities and debilitating chronic diseases.[1-3] While it is true that it is never too late to become health conscious and reap the benefits of a healthy lifestyle [4, 5], the fact remains that the sooner we start the better off we will be as we get older.[6, 7] If you are in your 20s, 30s or early 40s, read on….
 
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Metformin: is it an anti-aging pill?

 

The science of aging is moving forward as scientists are elucidating the biology of aging. The ultimate goal is to develop treatments that delay aging, and in so doing, delay the development of aging-related diseases.[1] 
 
Aging is the greatest risk factor for the majority of chronic diseases that are driving morbidity and health costs [2], but the aging process can be delayed with lifestyle (exercise and nutrition), genetics, and pharmacologic approaches.[3-8] 
 
The so called “geroscience hypothesis” (“gero” is short for gerontology, which is the scientific study of the process of aging and its consequences)  holds that treatments that are targeting fundamental processes of aging may delay, prevent, alleviate, or reverse a wide range of diseases and conditions for which age is the primary non-modifiable risk factor.[1] Interventions that target fundamental aging processes have the potential to transform human health and health care.[9]
 
Excitement is now high because time has come for the first study to test the effect of metformin on aging-related outcomes in humans and see if it qualifies as an "anti-aging pill"... 
 
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Dr. Pierce's Medical Organization Affiliations

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