Things You Should Know About Menopause
Oh, the joy of being a woman...Menstrual cycles (commonly known as periods) impact women’s lives on a monthly basis starting at puberty for several decades, with the exception of pregnancies when periods cease for a period of 9 months. However, these menstrual cycles do not last forever. Periods will eventually come to a halt permanently, also known as menopause. Understanding menopause is important for men as well as women, since it will affect how men communicate with the women in their lives such as a spouse, mother, sister, female friends, or other relatives during the menopause stage that may last up to a decade. Menopause is popularly correlated to hot flashes and the ceasing of womens’ periods but there is a lot more to it than that. Here are some things you need to know regarding the menopause stages women are going through or will eventually go through and treatments recommended by experts.
Similar to other fibrotic diseases, the cause of Peyronie’s disease (PD) is still unclear. This disease is defined by fibrous plaque that accumulates on the soft tissue of the male sexual organ; this causes the organ to bend significantly as well as cause erectile dysfunction, followed by pain and difficulty in sexual performance. Even with the current wide array of medications, procedures, natural remedies, and alternative options available, finding effective treatment of Peyronie’s disease remains a challenge to this day.
When you see the term “testosterone,” we typically associate it with masculinity and men. However, women generate testosterone too. So, what exactly is testosterone? Testosterone is a steroid hormone that plays a significant role in the male sperm production and produced in women’s ovaries in much smaller amounts. Rising levels of testosterone stimulates physical and chemical changes for boys and men such as increased muscle, pubic hair growth, deeper lengthened vocal chords, and increased sexual desire.
Testosterone production significantly spikes during puberty and starts to drop after age 30. Having optimal levels of the steroid hormone is essential from puberty throughout adulthood for general health, aids in preventing certain chronic diseases, and increases energy levels. As our levels of testosterone naturally decrease over time, rest assured there are ways to naturally boost it back up.
In discussions about side effects of testosterone treatment, prostate cancer and heart disease get most attention. However, as we have described in several study reports published here in the “Research News” section, the widespread fear of prostate cancer and heart disease is unfounded and not supported by medical research.
The expected potential side effect of testosterone treatment - which in fact is a therapeutic effect in men with anemia [1-3] - is an increased level of red blood cells, known as erythrocytosis or polycythemia.[4-7] In the context of testosterone treatment, erythrocytosis and polycythemia are used interchangeably to refer to an abnormal increase of red blood cells or hematocrit, which may increase blood viscosity (“blood thickness”).[8, 9]
However, it should be pointed out that technically, erythrocytosis is just red blood cell elevation, while polycythemia involves elevation of red blood cells, white blood cells, and platelets. Using these terms as synonyms can cause confusion. In polycythemia, it is likely the increase in platelets that is the major culprit of blood clots.
Elevated hematocrit is the most common side-effect of testosterone treatment.[4-7] The clinical significance of a high hematocrit level is unclear, but it may theoretically be associated with an increased risk of thrombosis (blood clots).
Here I summarize the results of an analysis of the effect of different testosterone preparations on hematocrit elevations, published in the journal Sexual Medicine Reviews.
Historically, testosterone has almost been a synonym for prostate cancer, and therefore many men have been - and still are - denied testosterone therapy, despite having testosterone deficiency.
A rapidly growing number of studies have challenged the long-standing belief about a putative detrimental association between testosterone and prostate cancer development and/or progression.[2-5] Here I summarize the results of a study published in The Aging Male, which investigated the incidence and severity of prostate cancer in testosterone treated versus non-testosterone treated patients who underwent prostate biopsy.
It is well-documented that the relation between testosterone deficiency and body fat is bi-directional; low testosterone levels contribute to the development of excessive body fat accumulation, and an excessive amount of body fat contributes to a reduction in testosterone levels.[1-3]
Here I present a series of three reports from a study that specifically investigated if testosterone therapy has beneficial effects on body composition, symptomatic response, adipokines (hormones secreted by fat cells, such as leptin and adiponectin) and gut hormones, over and above caloric restriction alone.[4-6]
- Compared to diet alone, combining diet + testosterone therapy results in a greater reduction in fat mass (-2.9 kg) and visceral fat, and a reduced loss of lean mass after 1 year.
- Dieting men who receive testosterone therapy display higher physical activity levels than dieting men not receiving testosterone therapy.
- The elevation in testosterone levels by diet alone is not enough to optimize body composition results. Diet alone results in less body fat reduction and more lean mass loss than diet + testosterone therapy.
- Diet + testosterone therapy ameliorates symptoms long-term after a diet. Diet alone does not confer long-term symptomatic improvements.
- Diet + testosterone therapy, but not diet alone, reduces leptin resistance.
- Testosterone treatment is NOT associated with risk of adverse cardiovascular events – the RHYME study
- Testosterone Therapy in Men with Prostate Cancer – Yes or No?
- How is anabolic steroid use different from testosterone replacement therapy?
- Dispelling the myth of testosterone treatment and prostate cancer