Ageless Forever Anti-Aging News Blog

Testosterone Boosting Medications and Cardiovascular Risk - a systematic review and meta-analysis

Accumulating evidence shows beneficial effect of testosterone therapy on a wide range of health outcomes, including inflammation, insulin sensitivity, muscle mass, body fat mass, lipid profiles,  endothelial, bone mineral density, energy and vitality, mood, sexual function and overall quality of life. [1-9]
 
Despite this, concerns have been raised that testosterone therapy could have detrimental effects on cardiovascular disease.
 
In this article I summarize results from a comprehensive systematic review and meta-analysis, the largest to date, of all placebo-controlled randomized clinical trials (RCTs) on the effect of testosterone therapy on cardiovascular-related outcomes.[10] 
 
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Omega-3 fat intake for prevention of skin aging

Photoaging is the process of aging of the skin due primarily to regular and long-term exposure to ultra-violet radiation. The long-chain omega-3 fatty acids (EPA and DHA) have been implicated in modulating inflammatory processes associated with the skin, and supplementation with 3 g EPA+DHA for 6 months has been shown to reduce both UVB-erythemal sensitivity (i.e. sun induced skin reddening) [1], sunburn and sun induced itchy rash.[2]
 
A recently published study in Journal of Dermatological Science [3] investigated the associations between daily omega-3 fat intake and the severity of skin photoaging...
 
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Primary Prevention as an Anti-Aging Strategy - the importance of starting down the right path

 
Risk factors and chronic diseases typically get most attention among middle-age and older folks. And rightly so, since that's when the manifestations of chronic diseases start to show up, and when people get reminded about their chronological age.
 
An integral component of anti-aging (aka successful aging or healthy aging) is the freedom of physical disabilities and debilitating chronic diseases.[1-3] While it is true that it is never too late to become health conscious and reap the benefits of a healthy lifestyle [4, 5], the fact remains that the sooner we start the better off we will be as we get older.[6, 7] If you are in your 20s, 30s or early 40s, read on….
 
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What is Preventive Medicine and Primary Prevention?

"An ounce of prevention - A pound of cure for an ailing health care system" [1]
 
Over the past decade, interest in anti-aging treatments and interventions aimed at promoting health, vitality and youthfulness over the life course into old age, has risen exponentially. The popularity and rise of anti-aging interventions has been fueled by the aging baby-boomer generation and the great dissatisfaction surrounding the current medical system in the US and many other Western nations. 
 
Are you frustrated with today's big-pharma dictated assembly line medicine with doctors who only spend 7 minutes per visit with their patients? Are you against the routine "have a symptom - take a pill" traditional medical system mantra that is so pervasive in modern medicine? Then preventive medicine, which is a unique medical specialty recognized by the American Board of Medical Specialties (ABMS), and primary prevention is for you…
 
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Incidence of Prostate Cancer after Testosterone Therapy for up to 17 years

One of the major concerns among doctors and patients with testosterone therapy is its allegedly negative effect on the prostate.[1] However, according to the current ISA, ISSAM, EAU, EAA, ASA clinical guidelines, there is no conclusive evidence that testosterone therapy increases the risk of prostate cancer or benign prostatic hyperplasia.[2]
 
The guidelines also state that there is also no evidence that testosterone treatment will convert subclinical prostate cancer to clinically detectable prostate cancer.[2]
 
Despite this, many men are being denied testosterone therapy because of undue fears that it would cause harm to the prostate. Here I summarize the results from a study that investigated incidence of prostate cancer with testosterone therapy for up to 17 years.[3]
 
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Adherence to testosterone therapy - short term treatment is not sufficient for achievement of maximal benefits

 

Testosterone therapy confers a wide range of health benefits for hypogonadal men, including improvements in body composition (reduction in body fat, increase in muscle mass), lipid profile cardiovascular function, insulin sensitivity/glucose metabolism, bone mineral density, inflammatory parameters, quality of life and longevity.[1] 
 
Despite this, there is a high discontinuation rate with testosterone therapy.[2, 3]
 
 
In this article I summarize results from two studies that investigated adherence to testosterone therapy and treatment patterns.[2, 3]
 
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Efficacy and safety of injectable testosterone undecanoate (Aveed or Nebido) for the treatment of hypogonadism

Since its approval in 2004, many clinical studies have been conducted with testosterone undecanoate, the first long-acting injectable form of testosterone.
 
Testosterone undecanoate has been proven to have an excellent safety profile and need only be administered four times annually to produce stable testosterone levels.[1]
 
Long-term studies have validated the clinical efficacy of testosterone undecanoate in maintaining stable therapeutic levels of testosterone and safely conferring the desired benefits of androgen replacement.[1]
 
Here I summarize the results from a comprehensive meta-analysis of all uncontrolled and placebo-controlled randomized clinical trials (RCTs) demonstrating the effect of injectable testosterone undecanoate on multiple clinical outcomes.[2]
 
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Testosterone Levels, Testosterone Therapy and Cardiovascular Risk in Men

Hypogonadism, also known as testosterone deficiency, is increasing in prevalence worldwide. While a rapidly expanding body of research is documenting the detrimental health consequences of hypogonadism, at the same time there is a prevailing concern and misunderstanding about the effects of testosterone therapy on cardiovascular risk.
 
In this article I present a summary of a recently published comprehensive review on the association of hypogonadism with cardiovascular risk factors, and the effect of testosterone therapy on those risk factors.[1]
 
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Is hypogonadism, aka "andropause", the male version of menopause?

Many men who reach middle-age start to experience symptoms that resemble those of menopause; reduced libido, lack of energy, weight gain, fatigue, depression and osteoporosis, to name a few.[1-5]
 
Therefore these conditions are frequently seen as being equivalent, and hypogonadism (which sometimes get the prefix "late onset") has therefore been called "andropause", "male climacteric", "male menopause" or "MANopause.[6, 7] 
 
However, this is very misleading. In this article I will contrast and comment on the differences between hypogonadism, also known as testosterone deficiency, and menopause.[8]
 
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Testosterone in women - is it physiological and clinically important?

Testosterone is popularly known as the "male" hormone. While it is true that men have much higher levels of testosterone than women, and that testosterone contributes to secondary sex characteristics that physiologically distinguish men from women (increased muscle mass and facial/body hair), this does not mean that testosterone isn't important in women.
 
In the same way that men need estrogen, aka the "female" hormone, for optimal health, women need testosterone for optimal health. This article will describe testosterone physiology in women and its importance for women's health, and refute the two prevailing myths that "testosterone is un-physiological in women", and that "there is no research or clinical experience supporting the use of testosterone therapy in women".... you may be surprised...!
 
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Dr. Pierce's Medical Organization Affiliations

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