Ageless Forever Anti-Aging News Blog

Combined Testosterone and GH therapy for best results on body composition and safety profiles

Prevention of age-related muscle loss (sarcopenia)

Many studies have highlighted the importance of investigating all major hormones, and correcting deficiencies and imbalances if present.[1-8] Given the known mechanisms of testosterone and GH/IGF-1 in building muscle (and possibly also DHEA in elderly) it is reasonable that age-related low levels of anabolic hormones contribute over time to sarcopenia and frailty.[1, 2, 4, 7, 9, 10]

Thus, multiple small effects in aggregate can lead to adverse loss of muscle and disability. In this scenario, if replacement was to occur, it would require lower doses of multiple anabolic hormones. An added benefit to this approach would be fewer side effects from the use of lower hormone doses [11]. In addition, multiple anabolic hormone replacement might also have beneficial additive or even synergistic effects.[11-13]

A notable study investigated whether supplementation with testosterone and GH together, in physiological doses, results in greater improvements in body composition and muscle performance in older men, compared to testosterone supplementation alone...

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Testosterone Thresholds and Muscle Mass Gains Needed to Enhance Muscle Strength and Function

In a previous article "Combined Testosterone and GH therapy for best results on body composition and safety profiles" I covered a study showing that testosterone replacement therapy alone produced significant gains in total lean body mass, leg/arm muscle mass, strength and aerobic endurance, together with significant reductions in whole-body and trunk fat. [1] 
 
In the same study, addition of GH (growth hormone) further enhanced these beneficial results. 
 
In a follow-up to that that study, the researchers looked deeper into the data with the following analyses: [20] 
 
- Pathway analysis to test the hypothesis that testosterone and GH affected muscle mass directly and that a threshold change in lean tissue (muscle) mass was needed to generate significant improvements in muscle performance and physical function. 
 
- Bootstrap analysis to determine threshold hormone levels associated with threshold changes in whole-body and appendicular lean mass that would be necessary for improving muscle performance and functional outcomes.
 
Here I report on the results of this insighful analysis...
 
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Fish Oil for Muscle Growth and Prevention of Muscle Loss with Aging

 
A key hallmark of aging is a progressive loss of muscle mass, which occurs independently of health status.[1] Exercise and nutrition are the two main anabolic stimuli for muscle growth and its maintenance throughout the life course.[2-11]
 
It is clear that maintaining high physical activity and exercise levels throughout ones lifespan reduces aging related loss of muscle mass and function, compared with living a sedentary life.[12-19]
 
However, even active older adults and master elite athletes still experience some loss of muscle and physical performance with advancing age.[8, 13, 20]
 
When it comes to nutrition, high protein intake [2, 3, 10, 21] and creatine supplementation [4-8, 22] are two of the best documented interventions, which together with resistance exercise training, result in greater increases muscle mass and strength in both young [21-23] and older people [2-8, 10], and prevent its loss with aging. Here I will present the relatively unknown effevts of fish oil (most well-known for its cardiovascular health promoting effects) on muscle growth (anabolism) and its possible contribution to prevention of aging related loss of muscle mass and function...
 
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Fish Oil for Fat Loss - can it really help you get in shape?

Fish oil is most known for its beneficial heart and cardiovascular effects, and continues to top the list of health promoting supplements. Fish oil is unique in its ability to protect against heart disease and promote cardiovascular health in all people, regardless of age or baseline health status [1, 2].
 
Fish oil improves the blood lipid profile and is especially effective at lowering triglycerides (a.k.a. blood fats).[3] It also has beneficial effects on blood platelet activity, blood thickness, as well as blood vessel (endothelial) function [4-11], blood vessel elasticity [12], and blood pressure [13, 14], among other things.
 
In 2004 FDA approved a prescription fish oil preparation for treatment of high triglycerides (hypertriglyceridemia) [3, 15, 16]. Accumulating research shows that fish oil also has other beneficial effects, which are more visually notable… notably, fat loss!
 
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Dr. Pierce's Medical Organization Affiliations

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