Ageless Forever Anti-Aging News Blog

Long-term testosterone treatment with different testosterone preparations - provocative results on diagnosis and adherence

Due to lack of consistent clear-cut guidelines for diagnosis and treatment of testosterone deficiency, there is a lot of confusion among both health professionals and suffering men. The multiple different testosterone preparations available further add to the complexity of testosterone treatment.

This article presents the intriguing results from a notable study that analyzed effects of testosterone therapy with seven different testosterone preparations in symptomatic men who had previously been denied treatment because of “normal” baseline testosterone levels.[1]
 
The results are quite provocative and highlight several important practical issues relating to diagnosis and treatment of hypogonadism…
 
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Everything We Learned About TESTOSTERONE Is WRONG - video presentation by Dr. Morgentaler

Historically testosterone therapy was only indicated in men with pituitary tumors and testicular dysfunction. Dr. Morgentaler pioneered the field when he started to treat men – who did not have any underlying pituitary tumors and testicular dysfunction - with Low-T with testosterone therapy. His patients reported improved erections, libido, orgasm, as well as increased energy, mood, cognition and wellbeing.
 
This use of testosterone therapy in otherwise healthy men defied standard medical practice in the 1990s...
 
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Testosterone Deficiency and Treatment - the FACTS

 
Testosterone deficiency and treatment is a very misunderstood and controversial topic among scientists, regulatory agencies (such as the FDA and EMA) and doctors, as well as the popular media.
 
On October 1, 2015, an international expert consensus conference about testosterone deficiency and its treatment was held in Prague, sponsored by King’s College London and the International Society for the Study of the Aging Male (ISSAM). The impetus for this meeting was to address the widespread misinformation and confusion about testosterone deficiency and testosterone therapy.[1]
 
The ultimate goal of this consensus conference was to document what is true or untrue about testosterone deficiency and testosterone therapy, to the best degree possible based on existing scientific and clinical evidence.
 
There were 18 experts from 11 countries on 4 continents. Specialties included urology, endocrinology, internal medicine, diabetology, and basic science research. Experts were invited on the basis of extensive clinical experience with testosterone deficiency and its treatment and/or research experience.
 
The final consensus on several key issues related to testosterone therapy was published in the form of 9 resolutions (i.e. firm decisions), coupled with expert comments.[2] These are summarized in table 1.
 
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Video Summary: Testosterone Deficiency and Treatment - International Expert Consensus Resolutions

In a previous article "Testosterone Deficiency and Treatment - the FACTS" I presented the conclusions from an International Expert Consensus Conference on Testosterone Deficiency and Its Treatment.[1]
 
Here I summarize the key points, and link to a video summary by Dr. Abraham Morgentaler, an internationally renowned testosterone scientist and clinician.
 
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Waist-to-Height Ratio as a Screening Tool for Testosterone Deficiency

A bidirectional relationship exists between excess body fat, and/or belly fat, and testosterone levels in men. That is, excess body (belly) fat decreases testosterone levels and may cause testosterone deficiency, and low testosterone levels increases body (belly) fat.[1-4]  I covered this in-depth in a previous article “Testosterone and Fat Loss - the Evidence”.
 
In “Keep your waist to less than half your height” I introduced the waist-to-height ratio and explained that it is a better tool for predicting health outcomes and mortality than is waist circumference alone. I have also covered the association between a large waist (i.e. belly) and reduced testosterone levels in "Young Men, Waist, Testosterone and Erectile Function: Low-T is not only an old man's issue".
 
Here I will summarize research showing that the waist-to-height ratio can also be used as a screening tool for testosterone deficiency. 
 
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Testosterone treatment is NOT associated with risk of adverse cardiovascular events – the RHYME study

It is well-documented that testosterone therapy effectively restores testosterone levels in hypogonadal men and improves many health outcomes, such as quality of life [1-4], libido [4, 5], metabolic parameters [5-9] and body composition.[4, 5, 9, 10]
 
However, a few conflicting studies raised concerns about the cardiovascular safety of testosterone therapy [11, 12], which in 2015 prompted the FDA to issue warnings to physicians and patients about potential cardiovascular risks of testosterone therapy.
 
In contrast, the European Medicines Agency (EMA) acknowledged the flaws of the conflicting studies and concluded that there is no consistent evidence of harm associated with testosterone therapy, regardless of mode of delivery.[13]
 
Here I summarize the cardiovascular results of the notable RHYME (The Registry of Hypogonadism in Men) study, which contrary to prior clinical trials, enrolled men with a wide range of comorbid illnesses and cardiovascular risk factors.[14] The aim was to evaluate the safety of testosterone therapy in a sufficiently diverse population to reflect real-world, clinical experience.[14]
 
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5 Ways to Naturally Boost Your Testosterone

testosterone

 

When you see the term “testosterone,” we typically associate it with masculinity and men. However, women generate testosterone too. So, what exactly is testosterone? Testosterone is a steroid hormone that plays a significant role in the male sperm production and produced in women’s ovaries in much smaller amounts. Rising levels of testosterone stimulates physical and chemical changes for boys and men such as increased muscle, pubic hair growth, deeper lengthened vocal chords, and increased sexual desire.


Testosterone production significantly spikes during puberty and starts to drop after age 30. Having optimal levels of the steroid hormone is essential from puberty throughout adulthood for general health, aids in preventing certain chronic diseases, and increases energy levels. As our levels of testosterone naturally decrease over time, rest assured there are ways to naturally boost it back up.

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5 Signs Your Testosterone is Too Low

low testosterone


Like all hormones, testosterone plays an important role in regulating a host of different processes in the body. There is no question maintaining optimal levels of testosterone is ideal to a healthy lifestyle. Testosterone is an essential hormone responsible for male development, masculine characteristics, building muscle, fueling sex drive, and receptors exists throughout the body. This hormone is primarily produced in the male testicles and womens’ adrenal glands. As we age, testosterone production begins to slow down. If you have low levels of testosterone, the consequences can greatly affect your health.

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6 Best Foods to Help Increase Low Testosterone

boost low testosterone

Having adequate levels of testosterone is a vital factor in determining your quality of life. For beginners, testosterone is a male sex hormone found in men and women found to be important for energy, fertility, healthy sexual functions, and building muscle. Testosterone is one of the main causes of physical changes for boys during puberty, like promoting deeper voice and hair growth. Generally, a person’s testosterone level will steadily decline as you age, depending on medical conditions, lifestyle choices, and other factors. A decreasing T level can result in a lot of changes in your body, including a lower sex drive.

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Dr. Pierce's Medical Organization Affiliations

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