Monica Mollica

Monica Mollica

Medical Writer & Nutritionist

MSc in Nutrition

University of Stockholm & Karolinska Institute, Sweden 

   Baylor University, TX, USA

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Effects of testosterone treatment on body fat, lean mass, symptoms and leptin resistance in obese men on a calorie-restricted diet

Effect of testosterone therapy on body composition and leptin resistance

 

It is well-documented that the relation between testosterone deficiency and body fat is bi-directional; low testosterone levels contribute to the development of excessive body fat accumulation, and an excessive amount of body fat contributes to a reduction in testosterone levels.[1-3]

Here I present a series of three reports from a study that specifically investigated if testosterone therapy has beneficial effects on body composition, symptomatic response, adipokines (hormones secreted by fat cells, such as leptin and adiponectin) and gut hormones, over and above caloric restriction alone.[4-6]

 

Key Points

-    Compared to diet alone, combining diet + testosterone therapy results in a greater reduction in fat mass (-2.9 kg) and visceral fat, and a reduced loss of lean mass after 1 year.

-    Dieting men who receive testosterone therapy display higher physical activity levels than dieting men not receiving testosterone therapy.

-    The elevation in testosterone levels by diet alone is not enough to optimize body composition results. Diet alone results in less body fat reduction and more lean mass loss than diet + testosterone therapy. 

-    Diet + testosterone therapy ameliorates symptoms long-term after a diet. Diet alone does not confer long-term symptomatic improvements.

-    Diet + testosterone therapy, but not diet alone, reduces leptin resistance.

 

Why I do what I do…

I am a former fitness model. Former because I’m now focusing on my professional career as a medical writer and following my mission in life, which is to help educate doctors on the latest medical research findings (I write continuing medical education (CME) material for health care professionals) and empower people to take control of their health. Here I will tell you why...
 
But I stay in modeling shape all year round even though I don’t pose for the cameras any more for a living. I am constantly being asked in the gym “how do you stay in shape all the time” and “when is your show”… so I felt l wanted share my story in writing because I think it can help many people who are struggling with sticking to regular exercise and healthy eating, as well as those who are undergoing life tradegies…
 
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