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Ageless Forever Anti-Aging News Blog

Testosterone Therapy vs. Estrogen Therapy in Surgically Menopausal Women - effectiveness comparison

In a previous article I outlined a study showing the effectiveness of testosterone therapy on menopausal symptoms in pre- and post-menopausal women. Here I will present and comment on an insightful study that compared head-to-head the effectiveness of testosterone therapy and estrogen therapy in surgically menopausal women who had their ovaries removed.[1]
 
STUDY DESIGN:
Before the surgical removal of both ovaries (bilateral ovariectomy) women were randomly assigned to either a testosterone alone, estrogen alone, or placebo groups. There were 10 patients in each group.
 
Mean age of the women was 46 years. They had underwent bilateral ovariectomy due to having uterine fibroids (aka myoma), which are non-cancerous (benign) tumors that develop in the womb (uterus).
 
HORMONE TREATMENTS:
 
The testosterone group received injectable testosterone (enanthate); 200 mg/ml.
 
The estrogen group received injectable estradiol; 10mg/ml.
 
The testosterone/estrogen group received injectable testosterone (enanthate) 150 mg + 8.5 mg estradiol/ml.
 
All groups received 1 ml intramuscular injections every 28 days for 3 months.
 
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Testosterone in women - is it physiological and clinically important?

Testosterone is popularly known as the "male" hormone. While it is true that men have much higher levels of testosterone than women, and that testosterone contributes to secondary sex characteristics that physiologically distinguish men from women (increased muscle mass and facial/body hair), this does not mean that testosterone isn't important in women.
 
In the same way that men need estrogen, aka the "female" hormone, for optimal health, women need testosterone for optimal health. This article will describe testosterone physiology in women and its importance for women's health, and refute the two prevailing myths that "testosterone is un-physiological in women", and that "there is no research or clinical experience supporting the use of testosterone therapy in women".... you may be surprised...!
 
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Testosterone Deficiency and Treatment - the FACTS

 
Testosterone deficiency and treatment is a very misunderstood and controversial topic among scientists, regulatory agencies (such as the FDA and EMA) and doctors, as well as the popular media.
 
On October 1, 2015, an international expert consensus conference about testosterone deficiency and its treatment was held in Prague, sponsored by King’s College London and the International Society for the Study of the Aging Male (ISSAM). The impetus for this meeting was to address the widespread misinformation and confusion about testosterone deficiency and testosterone therapy.[1]
 
The ultimate goal of this consensus conference was to document what is true or untrue about testosterone deficiency and testosterone therapy, to the best degree possible based on existing scientific and clinical evidence.
 
There were 18 experts from 11 countries on 4 continents. Specialties included urology, endocrinology, internal medicine, diabetology, and basic science research. Experts were invited on the basis of extensive clinical experience with testosterone deficiency and its treatment and/or research experience.
 
The final consensus on several key issues related to testosterone therapy was published in the form of 9 resolutions (i.e. firm decisions), coupled with expert comments.[2] These are summarized in table 1.
 
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Video Summary: Testosterone Deficiency and Treatment - International Expert Consensus Resolutions

In a previous article "Testosterone Deficiency and Treatment - the FACTS" I presented the conclusions from an International Expert Consensus Conference on Testosterone Deficiency and Its Treatment.[1]
 
Here I summarize the key points, and link to a video summary by Dr. Abraham Morgentaler, an internationally renowned testosterone scientist and clinician.
 
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