When it comes to health promotion and longevity, DHEA is a supplement which deserves more attention than it has been getting.
DHEA levels (the main circulating form of DHEA in the bloodstream is DHEAS) decrease approximately 80% between ages 25 and 75 year.[1, 2]This large decline in DHEA has led to interest in the possibility that aging related DHEA deficiency may play a role in the deterioration in physiological and metabolic functions with aging, and in the development of chronic diseases.
In support of this, it has been reported that DHEA level is negatively correlated with mortality and risk of developing cardiovascular disease (CVD) (i.e. lower DHEA(S) levels are associated with higher mortality and CVD risk).[3-5]More recently it has been found that a steep decline or extreme variability over time in DHEA(S) levels is associated with higher mortality, more so than baseline DHEA(S) levels.
It has been reported that DHEA levels are inversely associated with arterial stiffness (i.e. lower DHEA levels are associated with increased arterial stiffness. [7, 12, 13] Therefore, it is possible that DHEA replacement in older adults could reduce arterial stiffness, and thereby contribute to reduction in CVD and mortality...
It is well-documented that testosterone levels decline with age in men.
After the age of 40 years, total testosterone decreases on average -4 ng/dL ( -0.124 nmol/L) per year  or 1.6% per year , and bioavailable testosterone by -2 to 3% per year. 
In older men (over 60 years of age), the average rate of decrement in total testosterone levels has been found to be 110 ng/dL every decade.
However, the relative contributions of changes in health and lifestyle to that decline have not been adequately evaluated. A notable study was set out to investigate this...
The objective of this study was to establish the relative importance of aging, health, and lifestyle in contributing to the testosterone decline in aging men.
A few days ago, Jan 29th 2014, a controversial study  was published showing that men aged 65 years and older, had a two-fold increase in the risk of heart attack in the 90 days after filling an initial TT
prescription, regardless of cardiovascular disease history. Among younger men below 65 years of age with a history of heart disease, the study reported two to three-fold increased risk of MI in the 90 days following an initial TT prescription.
This study has stirred up heated discussions and media headlines. Let's dissect it and look under the hood...