Testosterone Replacement Therapy
Study shows only a combination of testosterone therapy and strength training results in an increase in both mechanical muscle function and muscle mass (LBM).
To examine the effect of strength training and testosterone therapy on mechanical muscle function and lean body mass (LBM) in aging men with low-normal testosterone levels in a randomized, double-blind, placebo controlled 24-week study.
"It is dangerous to be right when the government is wrong." - Voltaire
For reasons that are not readily apparent, there appears to be a conservative political movement that opposes the use of testosterone in older men. This was clearly demonstrated by the report of the Institute of Medicine, which felt that testosterone is not yet ready for prime time and that there is still a need for studies to prove its efficacy . Along the same lines, the guidelines of the Endocrine Society on testosterone use in older men seem to be ultra-cautious . But fortunately, there are also other, more liberal guidelines and recommendations [3-5].
Probably no other medical issue has been bombarded by the influx of “expert” views from all walks of life; from endocrinologists and psychiatrists to urological surgeons and gerontologists, from the lay press to the regulatory agencies and from the pharmaceutical to the entertainment industries. The dismal result of all this free-for all cacophony of opinions is a great deal of confusion, erroneous information and significant detriment to patients and physicians alike.
Let's take an in-depth look at the reasons for the negative attitudes to male testosterone replacement therapy (I will cover post-menopausal testosterone replacement in an upcoming article), and the hard scientific data that refutes it...
This is an abstract from an interesting debate among leaders in the field of Testosterone and Men's Health.
Is there any unequivocal evidence that testosterone (T) can stimulate growth and aggravate symptoms in men with locally advanced and metastatic prostate cancer (PCa)?
This is not a controversial point: the answer is yes.
However, this evidence does not imply that PCa is a result of T or therapy with T (TTh) of hypogonadal men.
A few days ago, Jan 29th 2014, a controversial study  was published showing that men aged 65 years and older, had a two-fold increase in the risk of heart attack in the 90 days after filling an initial TT
prescription, regardless of cardiovascular disease history. Among younger men below 65 years of age with a history of heart disease, the study reported two to three-fold increased risk of MI in the 90 days following an initial TT prescription.
This study has stirred up heated discussions and media headlines. Let's dissect it and look under the hood...
- Testosterone Replacement Therapy (TRT) in Testosterone Deficient men - effects on fat loss, waist reduction and metabolic syndrome components
- Testosterone Replacement Therapy (TRT) - does it really increase risk of heart attack? Commentaries from medical organizations
- Effects of 6-year Long-Term Testosterone Replacement Therapy (TRT) in Patients with ‘‘Diabesity’’