Ageless Forever Anti-Aging News Blog

Testosterone Replacement Therapy


When you see the term “testosterone,” we typically associate it with masculinity and men. However, women generate testosterone too. So, what exactly is testosterone? Testosterone is a steroid hormone that plays a significant role in the male sperm production and produced in women’s ovaries in much smaller amounts. Rising levels of testosterone stimulates physical and chemical changes for boys and men such as increased muscle, pubic hair growth, deeper lengthened vocal chords, and increased sexual desire.

Testosterone production significantly spikes during puberty and starts to drop after age 30. Having optimal levels of the steroid hormone is essential from puberty throughout adulthood for general health, aids in preventing certain chronic diseases, and increases energy levels. As our levels of testosterone naturally decrease over time, rest assured there are ways to naturally boost it back up. Read more


Low T in Men and Women

Since women already produce very little testosterone, their levels drop even lower after reaching menopause, typically around the age of 45-50 when women’s menstrual cycles cease. Low levels of testosterone in women are commonly linked to the cause of headaches, anxiety, and decreased sexual drive. Men’s testosterone gradually decreases over time, usually after reaching their mid-thirties. Signs of low testosterone in men include depression, bone loss, fatigue, and erectile dysfunction. In addition to blood testing, you can take a Low T questionnaire to determine if your testosterone levels may be insufficient.   


Ways to Boost Testosterone

Increasing T levels in your body can help increase muscle mass, improve health and sexual well-being for both men and women. Here are some ways to naturally boost your hormone levels to ensure optimal health.


1. Exercise

One of the most effective ways of boosting testosterone is physical activity. Studies have shown that people who exercise frequently have higher testosterone levels than people that exercise little to none at all. Resistance training, such as weight-lifting and high-intensity exercise are known to be the most testosterone-inducing forms of physical activity for short-term and long term benefits.


2. Consume Protein, Fats & Carbs

Your diet also has a major impact on your testosterone level. You can monitor your hormone levels by focusing on your long-term caloric intake and diet. Poor dieting or overeating may cause your testosterone levels to fluctuate. Maintaining a balanced diet including enough protein, carbs, and fats can assist in healthy hormone levels as well as help with fat loss. Plenty of protein helps build muscle mass, carbohydrates help supply energy for resistance training, and healthy fats help maximize testosterone production




3. Get more sunlight

You won’t find a better natural testosterone booster than the vitamin d from sunlight. The European Journal of Endocrinology conducted a study and found direct correlation that men deficient in vitamin d also had insufficient testosterone levels. Worried about getting too much sun? Once your body produces enough vitamin d from the sun, the ultraviolet rays will stop your body from overproducing. It is important to always wear sufficient sunscreen to help protect from sunburn and other harmful effects from overexposure of the sun’s rays. About 10-20 minutes of sun a day during spring and summer seasons and 2 hours a day in winter is recommended to give you the adequate vitamin to increase testosterone and reap other benefits.


4. Take supplements

The benefits of taking multivitamins are still up for debate, but taking specific vitamins and minerals may prove to be very helpful. Zinc, a mineral found in cells throughout the body supports the functionality of the body’s immune system, stimulates cell growth, injury healing, and helps break down carbohydrates. Taking zinc supplements have been known to raise testosterone. Other studies also suggest taking vitamin a, c, d, and e supplements to increase hormone production and sex drive, with zinc and vitamin d being the most beneficial.




5. Get enough rest

Getting high quality sleep also affects your testosterone. A long-term study found people who are sleep-deprived (typically sleeping for only 5 hours or less a night)  also linked to a 15% decrease in testosterone levels. Normal testosterone production requires undisturbed, restful sleep also known as REM (rapid eye movement) sleep. Sleep disturbance can increase more stress over time, which can also cause low T. Although some people argue they are able to function on less sleep, research suggests about 7-10 hours of sleep a night is ideal for testosterone and long-term health.



Healthy testosterone levels are fundamental for both men and women to manage a healthier lifestyle. Not only does optimal testosterone levels help with sexual function, it promotes muscle growth, cognitive function and decreases chances of health risks and obesity. As we grow older and our hormone levels begin to decrease, it is wise to take charge in finding the best natural ways to boost it back up to continue to enjoy a healthy life. At Ageless Forever, we specialize in Testosterone Replacement Therapy (TRT) in order to examine and monitor T levels as well as other important hormones for both men and women to help slow and reverse the effects of aging. We believe in providing you the most accurate and up-to-date information and tools required to live a life full of vigor, health, and happiness.


Make sure you check out our anti-aging news blog for more researched information on related topics.

Testosterone Therapy and Cardiovascular Risk - Advances and Controversies

One of the most debated issues related to testosterone therapy is its effects on cardiovascular risk and clinical events, like for example heart attack.
January 27th, 2015 a comprehensive medical review paper was published, addressing the controversial topic of testosterone therapy and cardiovascular risk.[65] It was written by the Androgen Study Group academicians and published in Mayo Clinic Proceedings.
Here I summarizes key conclusions from this milestone medical review.

Testosterone, Mortality and Longevity

Population studies show that men with low or low-normal testosterone levels are at an increased risk of mortality compared to those with higher levels, and that cardiovascular disease accounts for the greater proportion of deaths in men with low testosterone.[1] 
Here I summarize a medical review paper which addressed the following two questions: [1]
1.  Is testosterone deficiency directly involved in the pathogenesis of these conditions or is it merely a biomarker of ill health and the severity of underlying disease processes?
2.  Does testosterone replacement therapy retard disease progression and ultimately enhance the clinical prognosis and survival?

Cardiovascular Risks and Elevations of Blood DHT Levels Vary by Testosterone Preparation




The cardiovascular effects of testosterone and testosterone therapy are subject to intense investigation in medical research and have recently generated heated discussions among healthcare professionals. 
While the main focus has been on testosterone per se, it is important to remember that testosterone is both a hormone in its own right, and a pro-hormone that gets converted to both estradiol and DHT (dihydrotestosterone). Estradiol and DHT exert effects themselves that are different from the effects of testosterone.
Therefore, when analyzing the effects of testosterone, especially supplemental testosterone administered as testosterone replacement therapy, it is critical to take into consideration how it affects downstream testosterone metabolites like estradiol and DHT.
Here I will present results from a recent systematic review and meta-analysis that specifically investigated how different routes of testosterone therapy administration (i.e different testosterone preparations) affect blood levels of testosterone and espcially DHT , and how this in turn relates to cardiovascular adverse events.[1]

Testosterone and Fat Loss - the Evidence


It is well documented that obesity may cause hypogonadism, and that hypogonadism may cause obesity [1-4] This has generated debate about what condition comes first; obesity or hypogonadism? And what should be the first point of intervention?
In this article I will summarize data from several reviews on the associations of hypogonadism and obesity [1-4], and make the case that these conditions create a self-perpetuating vicious circle. Once a vicious circle has been established, it doesn’t matter where one intervenes; one can either treat the obese condition or treat hypogonadism first. The critical issue is to break the vicious circle as soon as possible before irreversible health damage arises. 
Nevertheless, as I will explain here, treating hypogonadism first with testosterone replacement therapy may prove to be a more effective strategy because it to a large extent “automatically” takes care of the excess body fat and metabolic derangements. In addition, treating hypogonadism first also confers psychological benefits that will help obese men become and stay more physically active. 

Testosterone Therapy Prevents Gain in Intra-Abdominal Fat and Counteracts Loss of Muscle in Non-Obese Aging Men

Testosterone deficiency is especially common in men who are obese and/or have the metabolic syndrome or diabetes, with a prevalence ranging from 35% to almost 80%.[1-5] However, there is a subgroup of non-obese men who have low testosterone levels and suffer from typical symptoms of low-T, but who do not (yet) have any co-morbidities. 
Many studies show that suboptimal testosterone levels may contribute to the development of obesity (including abdominal obesity) [6, 7], metabolic syndrome [8-13] and/or diabetes.[9, 14-20] Therefore, testosterone therapy in non-obese men with testosterone deficiency may be an effective intervention to correct not only symptoms associated with hypogonadism, but also prevent the development of obesity, metabolic syndrome and/or diabetes.
A notable study was set out to specifically investigate this…

Estrogen elevations in response to Testosterone Therapy – to treat or not?


During testosterone therapy, total and free estradiol (the main form of estrogen) levels increase dose-dependently in both young (aged 19-35 year old) and 52 older (aged 59-75 year old) men, and more so in older men compared to younger men.[1]
The potential clinical consequences of higher estradiol levels and higher estradiol-to-testosterone ratios in older men remains poorly understood, and the optimal management of high-normal or elevated estrogens is controversial among clinicians.[2]
Interestingly, in some patients, an initial elevation in estradiol is followed by decreased estradiol after prolonged testosterone therapy.[3, 4] This may be due to reduced body fat mass or decreased testosterone levels over time with fixed dose treatments. 
Here you will get advice on how to best approach estrogen management while on testosterone therapy…

Testosterone Boosting Medications and Cardiovascular Risk - a systematic review and meta-analysis

Accumulating evidence shows beneficial effect of testosterone therapy on a wide range of health outcomes, including inflammation, insulin sensitivity, muscle mass, body fat mass, lipid profiles,  endothelial, bone mineral density, energy and vitality, mood, sexual function and overall quality of life. [1-9]
Despite this, concerns have been raised that testosterone therapy could have detrimental effects on cardiovascular disease.
In this article I summarize results from a comprehensive systematic review and meta-analysis, the largest to date, of all placebo-controlled randomized clinical trials (RCTs) on the effect of testosterone therapy on cardiovascular-related outcomes.[10] 

Incidence of Prostate Cancer after Testosterone Therapy for up to 17 years

One of the major concerns among doctors and patients with testosterone therapy is its allegedly negative effect on the prostate.[1] However, according to the current ISA, ISSAM, EAU, EAA, ASA clinical guidelines, there is no conclusive evidence that testosterone therapy increases the risk of prostate cancer or benign prostatic hyperplasia.[2]
The guidelines also state that there is also no evidence that testosterone treatment will convert subclinical prostate cancer to clinically detectable prostate cancer.[2]
Despite this, many men are being denied testosterone therapy because of undue fears that it would cause harm to the prostate. Here I summarize the results from a study that investigated incidence of prostate cancer with testosterone therapy for up to 17 years.[3]

Adherence to testosterone therapy - short term treatment is not sufficient for achievement of maximal benefits


Testosterone therapy confers a wide range of health benefits for hypogonadal men, including improvements in body composition (reduction in body fat, increase in muscle mass), lipid profile cardiovascular function, insulin sensitivity/glucose metabolism, bone mineral density, inflammatory parameters, quality of life and longevity.[1] 
Despite this, there is a high discontinuation rate with testosterone therapy.[2, 3]
In this article I summarize results from two studies that investigated adherence to testosterone therapy and treatment patterns.[2, 3]
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