The consequences of low testosterone levels (aka low-T) have been primarily investigated in middle-age and older men. However, low-T in young men aged 20-39 years can confer health risks as well...
Low total testosterone levels are associated with an adverse blood lipid profile, which includes high TG and low HDL, [1, 2] and a decline in total testosterone levels predisposes men to increased risk of cardiovascular disease (CVD) and mortality.[3-7]
Prediabetes is a condition in which blood glucose level is higher than normal but does not reach the level for diabetes diagnosis.[1, 2] Studies have shown that people with prediabetes tend to develop type 2 diabetes within 10 years, and are at increased risk for cardiovascular disease.
Among US adults over 18 years, the prevalence of prediabetes has increased from 29.2% in 1999 to 36.2% in 2010. Considering the entire US population in 2010 (approx. 309 million, data from US Cencus), this corresponds to 112 million US adults, or over one third of the US population.
Data from non-diabetic men have revealed an inverse association between insulin resistance and testosterone levels; i.e. a higher degree of insulin resistance is associated with lower testosterone levels.[4-6] This raises the question whether prediabetes, which is a state of increased insulin resistance, is also associated with low testosterone. However, few studies have investigated testosterone levels in men with prediabetes, and the risk of testosterone deficiency in men with prediabetes has not been reported.
Because the prevalence of prediabetes is affecting such a large number of Americans, and is on the rise, it is important to investigate how this condition might affect testosterone levels. Knowing that can help
detect men who are likely to have testosterone deficiency and might be at risk for health derangements caused by low-T.