Testosterone Replacement Therapy
Testosterone Deficiency - Prevalence and Treatment Rates
- Published in Testosterone Replacement Therapy
- Written by Monica
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Testosterone Treatment and Heart Attack Risk - new study shows testosterone treatment can even be beneficial
- Published in Testosterone Replacement Therapy
- Written by Monica
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Multiple beneficial effects of testosterone replacement therapy in men with testosterone deficiency
- Published in Testosterone Replacement Therapy
- Written by Monica
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How Is Testosterone Deficiency "Low-T" Diagnosed? - Things you need to know before going to your doctor
- Published in Testosterone Replacement Therapy
- Written by Monica
Testosterone and Prostate Cancer - Bye Androgen Hypothesis, Welcome Saturation Model
- Published in Testosterone Replacement Therapy
- Written by Monica
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The Androgen Study Group - Cutting Through Misleading Headlines and Exposing the Truth about Testosterone Therapy and Health
- Published in Testosterone Replacement Therapy
- Written by Monica
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Muscle function and lean body mass during testosterone therapy combined with strength training and in aging men
- Published in Testosterone Replacement Therapy
- Written by Monica
Study shows only a combination of testosterone therapy and strength training results in an increase in both mechanical muscle function and muscle mass (LBM).
OBJECTIVES:
To examine the effect of strength training and testosterone therapy on mechanical muscle function and lean body mass (LBM) in aging men with low-normal testosterone levels in a randomized, double-blind, placebo controlled 24-week study.
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Effects of 6-year Long-Term Testosterone Replacement Therapy (TRT) in Patients with ‘‘Diabesity’’
- Published in Testosterone Replacement Therapy
- Written by Monica
March 6th 2014 FDA approved Aveed for treatment of male hypogonadism, aka testosterone deficiency.[1] Aveed is a long-acting form of injectable testosterone called testosterone undecanoate. In Europe, testosterone undecanoate (under the name Nebido) has a long successful TRT track record for treatment of testosterone deficiency and its consequences (especially obesity, the metabolic syndrome and diabetes).[2-16]
In contrast to shorter acting forms of testosterone (e.g. cypionate), testosterone undecanoate only needs to be injected every 6 to 12 weeks, and thereby offers practical benefits to patients. (Comment: for Nebido (1000 mg per 4 ml) the initial interval is 6 weeks, followed by intervals of 10-14 weeks; for Aveed (750 mg per 3 ml) the initial interval is 4 weeks, followed by 10-week intervals).
Five days after the FDA approval a notable and impressive 6-year long TRT study was published, confirming the health benefits of TRT that have previously been found in shorter term studies... [44]
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Testosterone Replacement Therapy (TRT) - does it really increase risk of heart attack? Commentaries from medical organizations
- Published in Testosterone Replacement Therapy
- Written by Monica
We previously posted a commentary on the recently published and notoriously flawed study which concluded that TRT increases risk for heart attack.
Does Testosterone Therapy Really Increase the Risk of Heart Attack?
This is the study which caused the media debates:
January 29th issue, the Scientific Journal PLOS (Public Library of Science) ONE published the article:
"Increased Risk of Non-Fatal Myocardial Infarction Following Testosterone Therapy Prescription in Men."
Here we have gathered commentaries from other medical professionals, all in one place:
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Testosterone Replacement Therapy (TRT) in Testosterone Deficient men - effects on fat loss, waist reduction and metabolic syndrome components
- Published in Testosterone Replacement Therapy
- Written by Monica
Testosterone deficiency in men, aka hypogonadism, is associated with increased total and abdominal fat mass, and reduced muscle mass, which negatively impacts body composition.[1, 2] This contributes to development of risk factors like insulin resistance, chronic inflammation, and atherogenic dyslipidemia (a triad of increased blood levels of small, dense LDL particles and triglycerides, and decreased levels of HDL particles), which increase the risk for cardiovascular disease, metabolic syndrome and diabetes.[1, 3-16]
Previous studies have shown that testosterone replacement therapy ameliorates these risk factors in testosterone deficient (hypogonadal) men; it increases insulin sensitivity [17-20] and HDL (the "good" cholesterol) [9, 10, 20, 21], and reduces waist circumference [9, 20, 22], fasting blood glucose [9, 20] triglycerides (blood fats)[9], LDL (the "bad" cholesterol) [19, 22-24], and several inflammatory markers.[17, 25]
A 2011 meta-analysis concluded that testosterone replacement therapy improves metabolic control, as well as reduces abdominal obesity.[9] Many studies have shown that testosterone replacement therapy in hypogonadal men increases muscle mass and reduces fat mass.[19, 26-32] Further, adding testosterone (50 mg/day for 1 year, administered as a transdermal gel) to a diet and exercise program results in greater therapeutic improvements of glycemic control and reverses the metabolic syndrome.[20]
Testosterone also has direct (non-obesity mediated) beneficial effects on many metabolic and cardiovascular risk factors [12, 33-37], and reduces death risk independently of body fat status.[38] In line with all these effects, low testosterone levels are associated with increased risk of cardiovascular complications [39], and all-cause and cardiovascular disease death [40-42]. Low testosterone may thus be a predictive marker for men at high risk of cardiovascular disease.[41] In a group of men aged 50-91 who were followed for 20 years, it was found that men whose total testosterone levels were in the lowest quartile (241 ng/dl or lower) were 40% more likely to die than those with higher levels, independent of age, adiposity, lifestyle or presence of cardiovascular risk factors.[38]
Thus, treatment of testosterone deficient men with testosterone has demonstrated considerable health benefits. Despite this, critics state that most of the studies on testosterone replacement therapy were too small. They also argue that the studies were of too short duration (most of them lasting 6-12 months), and that the long-term effects of testosterone on body composition are not known.
Two 5 year long studies were just published that addressed the duration and small study size shortcomings in previous research...