Ageless Forever Anti-Aging News Blog

Low testosterone levels are associated with a more than 2-fold increased risk of mortality in men aged 20-79

A notable study shows that men aged 20–79 who have low testosterone levels below 8.7 nmol/L (250 ng/dL) have a more than two-fold increased risk of mortality from all causes, compared with those with higher serum testosterone levels.

Importantly, this risk is independent of age, waist circumference, smoking habits, high-risk alcohol use, and physical activity.


Background

The association of low serum testosterone levels with mortality has gained strength in recent research. However, there are few population-based studies on this association.


Objective

This study examined whether low serum testosterone levels are a risk factor for all-cause or cause-specific mortality in a population-based sample of men aged 20–79.

Methods

We used data from 1954 men recruited for the prospective population-based Study of Health in Pomerania, with measured serum testosterone levels at baseline and 195 deaths during an average 7.2-year follow-up.

A total serum testosterone level of less than 8.7 nmol/L (250 ng/dL) was classified as low.

The relationships of low serum testosterone levels with all-cause and cause-specific mortality were analysed by Cox proportional hazards regression models.

Results

Men with low serum testosterone levels had a significantly higher mortality from all causes than men with higher serum testosterone levels (HR 2.24; 95% CI 1.41–3.57).

After adjusting for waist circumference, smoking habits, high-risk alcohol use, physical activity, renal insufficiency, and levels of dehydroepiandrosterone sulfate (DHEAS), low serum testosterone levels continued to be associated with increased mortality (HR 2.32; 95% CI 1.38–3.89).

In cause-specific analyses, low serum testosterone levels predicted increased risk of death from cardiovascular disease (CVD) (HR 2.56; 95% CI 1.15–6.52) and cancer (HR 3.46; 95% CI 1.68–6.68), but not from respiratory diseases or other causes.

Conclusion

Low serum testosterone levels were associated with an increased risk of all-cause mortality independent of numerous risk factors. As serum testosterone levels are inversely related to mortality due to CVD and cancer, it may be used as a predictive marker to improve the ability to predict health risks.


Reference:
Haring R, Völzke H, Steveling A, Krebs A, Felix SB, Schöfl C, Dörr M, Nauck M, Wallaschofski H.Low serum testosterone levels are associated with increased risk of mortality in a population-based cohort of men aged 20-79. Eur Heart J. 2010 Jun;31(12):1494-501

Last modified on Wednesday, 27 May 2015 18:33
Monica Mollica

Medical Writer & Nutritionist

MSc in Nutrition

University of Stockholm & Karolinska Institute, Sweden 

   Baylor University, TX, USA

back to top

Dr. Pierce's Medical Organization Affiliations

  • 1-a4m.jpg
  • 2-ACAM.jpg
  • 3-AMMG.jpg
  • 4-American-Board-Anti-Aging-Regenerative-Medicine.jpg
  • 5-AAPMR.jpg
  • 6-acoep.jpg
  • 7-ISSM.jpg
This module can not work without the AcyMailing Component